基于粗粒化的流感病毒蛋白进化树构建<sup>*</sup>

doi:10.16451/j.cnki.issn1003-6059.201610007

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Abstract Based on the coarse graining theory, a method for constructing phylogenetic tree of flu virus proteins is proposed by combining total 127 065 hemagglutinin and neuraminidase protein sequences. Firstly, to determine the appropriate granularity, a feature vector is obtained to present a virus protein sequence and then an approach is given to construct hierarchical structure of virus system by analyzing similarity among multi-protein sequences. The suitable number of clusters is determined according to hierarchical evaluation index based on the system structure. Furthermore, on the basis of the nearest-to-center principle, the significant viruses can be selected to represent characteristics of the whole class. Finally, the phylogenetic tree is established through the distance metric. The test result indicates that the influenza viruses with same host, similar time span, close outbreak location and same names are more likely to belong to the same branch. The results are identical with that of the existing literature on flu virus. The results provide a foundation for investigating the mutation, evolution and prediction of flu viruses.

Key words： Influenza Virus Phylogenetic Tree Coarse Graining Structural Clustering Big Data Processing

Received: 15 May 2015

ZTFLH:	TP 391
	O 29

Fund:Supported by National Natural Science Foundation of China (No.11371174), International Science and Technology Cooperation Program of China (No.2011DFR70500)

About author:: (LI Yang, born in 1991, master student. His research interests include intelligent computing and bioinformatics.)
(TANG Xuqing(Corresponding author), born in 1963, Ph.D., professor. His research interests include intelligent computing, bioinformatics and modeling and simulation of ecological system.)

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Cite this article:

LI Yang,TANG Xuqing. Construction of Phylogenetic Tree of Flu Virus Proteins Based on Coarse Graining[J]. , 2016, 29(10): 936-942.

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http://manu46.magtech.com.cn/Jweb_prai/EN/10.16451/j.cnki.issn1003-6059.201610007 OR http://manu46.magtech.com.cn/Jweb_prai/EN/Y2016/V29/I10/936

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